- Title
- Wave reflection: More than a round trip
- Creator
- Afkhami, Rashid; Johnson, Sarah
- Relation
- Medical Engineering and Physics Vol. 92, Issue June 2021, p. 40-44
- Publisher Link
- http://dx.doi.org/10.1016/j.medengphy.2021.04.005
- Publisher
- Elsiver
- Resource Type
- journal article
- Date
- 2021
- Description
- Reflected pressure waves are key to the understanding of vascular ageing, a prominent factor in major cardiovascular events. Several different metrics have been proposed to index the effect of wave reflection on the pressure waveform and thereby serve as an indicator of vascular ageing. The extent to which these indices are influenced by factors other than vascular health remains a matter of concern. In this paper, we use transmission-line theory to derive a mathematical model for the reflection time (Trefl), and the augmentation index (AI), assuming a general extended model of the arterial system. Then, we test the proposed model against values reported in the literature. Finally, we discuss insights from the model to common observations in the literature such as age-related “shift” in the reflection site, the variation of AI with heart rate, and the flattening of Trefl in older participants.
- Subject
- ageing; arteries; reflection time; wave reflection; augmentation index; blood pressure
- Identifier
- http://hdl.handle.net/1959.13/1449470
- Identifier
- uon:43670
- Identifier
- ISSN:1350-4533
- Language
- eng
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